Study Of The Response Of Immune System On Kawasaki Disease

Kawasaki disease is a very dangerous disease that affects the human body vigorously. This disease has not yet been identified how it affects the human body which is why it is very critical. The Kawasaki disease has many different symptoms including red eyes, rashes on the skin, fever and other complications that can be dangerous. This disease affects mostly infants and children at a young age.

However, a recent study was conducted by a team of researchers which focused on understanding the response of the immune system against Kawasaki disease for viral families. The study and the results will be presented in the conference for children known as the Pediatric Academic Societies (PAS) 2019 Meeting, taking place on April 24 – May 1 in Baltimore.

The study was led by Doctor Anne Rowley. She commented on the results obtained saying, “To identify antigens targeted by the antibody response of children with KD, we identified plasmablasts that were clonally expanded in the peripheral blood of 11 children with KD and made monoclonal antibodies from these plasmablasts. Monoclonal antibodies from nine of the 11 patients identified intracytoplasmic inclusion bodies in ciliated bronchial epithelium of fatal KD cases. A subset of these antibodies recognizes peptides from a hepacivirus non-structural protein, and an optimized peptide blocked binding of these antibodies to the inclusion bodies, demonstrating the presence of a hepacivirus-like protein in the inclusion bodies. These results strongly suggest that a new human virus, closely related to the hepaciviruses and with a respiratory portal of entry, is etiologically related to KD.”