Dermcidin In Sweat Acts As An Anti-Microbial Peptide To Cure Hidradenitis Suppurativa

Many different diseases occur which are rare and hard to understand. One of this disease is a skin disease called hidradenitis suppurativa (HS) which affects only 1%-4% of people in the world (young adults). This disease has not yet been treated effectively and may need more studies to be conducted to help understand.

A researcher conducted by a team of scientists at George Washington University (GW) was able to find a connection between Dermcidin and HS. Dermcidin is a substance found in the sweat of humans which acts as an anti-microbial peptide. The study showed results suggesting that Dermcidin might actually work as pathogenesis that might affect HS and cure it.

The study and results were published in the Clinical and Experimental Dermatology by lead author Victoria Shanmugam. Dr. Victoria is an associate professor of medicine at the GW School of Medicine and Health Sciences.

She commented on the results obtained in the study saying, “Until now, the molecular drivers of HS have been poorly understood. Traditional therapies have thus far been disappointing. However, TNF-α inhibitors like infliximab and adalimumab have shown efficacy. These findings suggest regulators of the innate immune response and particularly antimicrobial peptide production may play a role in HS pathogenesis.”

The study will be further developed to help understand how the substance act on the disease. Accordingly, amendments will be made to help cure and treat the disease.